ASPIRIN TABLET COATING DELAMINATION
About the sample: Aspirin tablets
Aspirin (ASA: acetylsalicylic acid) is used to reduce pain, fever, or inflammation. Aspirin tablets are often enteric-coated. The coating prevents the tablet from dissolving in the stomach and cause bleeding, but it dissolves in the small intestine instead. The coating should be uniform, fully covering the tablet without cracks or delamination. X-ray CT (computed tomography) can visualize these tablet coatings non-destructively.
- In this example, an aspirin tablet was scanned using a submicron-resolution CT scanner, nano3DX.
- The coating thickness was evaluated from the CT image.
1. CT scan
An enteric-coated aspirin tablet was scanned to produce the 3D grayscale CT image. The aspirin and hydrotalcite layers are clearly observed.
2. Coating evaluation
The gray level in CT data (left) represents the relative density. The coating has a higher density than aspirin and appears white in the image while the air appears dark. Under the 50 microns thick coating, about a 90 microns wide gap is seen at the corner of the tablet indicating the coating is delaminated.
Tablet crystallinity analysis
Brand name vs generic atorvastatin tablets comparison
Microparticle coating analysis
Rapid-release pain medication capsule comparison
Multivitamin tablet analysis
Famotidine tablet comparison
Aspirin tablet coating delamination
Degradation of sustained-release dosage tablet
Compression methods comparison